AP Exclusive: US scientists try 1st gene editing in the body

OAKLAND, Calif. (AP) — Scientists for the first time have tried editing a gene inside the body in a bold attempt to permanently change a person’s DNA to cure a disease. The experiment was done Monday in California on 44-year-old Brian Madeux.

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AP Exclusive: US scientists try 1st gene editing in the body

The creator of the pig-human chimera keeps proving other scientists wrong

Juan Carlos Izpisua Belmonte had spent years probing the inner workings of embryos, ferreting out the genes that give a body its shape or allow wings to form instead of legs. He’d tracked wafting chemical messengers that, like traffic police, guide streams of dividing cells either left or right.

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The creator of the pig-human chimera keeps proving other scientists wrong

Scientists take a big step toward creating custom organisms

Scientists dream of using custom organisms to fight illnesses or even build computers, but there’s a problem: it’s difficult to make the sweeping genetic changes that would give you exactly the lifeform you need.

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Scientists take a big step toward creating custom organisms

Aging Is Reversible—at Least in Human Cells and Live Mice

New research suggests it is possible to slow or even reverse aging, at least in mice, by undoing changes in gene activity—the same kinds of changes that are caused by decades of life in humans.

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Aging Is Reversible—at Least in Human Cells and Live Mice

Fountain-of-youth molecules make mice young again, extending their lives

The same four molecules that revolutionized research on stem cells can also reverse aging in mice, scientists reported Thursday, a finding that could herald new approaches to trying to extend human life.

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Fountain-of-youth molecules make mice young again, extending their lives

TIME Person of the Year Runner Up: CRISPR Scientists

Dr. Carl June’s lab at the University of Pennsylvania looks like any other biology research hub. There are tidy rows of black-topped workbenches flanked by shelves bearing boxes of pipettes and test tubes. There’s ad hoc signage marking the different workstations.

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TIME Person of the Year Runner Up: CRISPR Scientists

Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

Two complementary methods were developed: sOPiTKO is a knock-out system that turns off genes by disrupting the DNA, while sOPTiKD is a knock-down system that silences the action of genes by disrupting the RNA.

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Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type